ZIA CP010176-10092 (ZIA) | |||
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Title | Clonal expansion of lymphocytes in multiple cohorts | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Rabkin | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $113,856 | Project Dates | 03/24/2004 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Hodgkins disease (5.0%) Leukemia (5.0%) Multiple Myeloma (5.0%) Non Hodgkins Lymphoma (85.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Clonal expansion of lymphocytes. The Branch will examine the role of genomic instability in the etiology of NHL with HIV-infection as well as in the general population, using materials from the Branch's First and Second Multicenter Hemophilia Cohort Studies (MHCS-I/-II) and male homosexual cohort, the PLCO cohort, and the DCEG NHL case-control study. This project builds upon the Branch+s previous observation of the t(8;14) translocation in circulating lymphocytes from HIV-infected patients without NHL. Peripheral blood lymphocytes will be examined for oncogenic chromosomal translocations associated with risk of subsequent NHL and/or clonally related to these tumors. Lymphoma specimens will be examined for tumor suppressor gene and oncogene alterations, and viral DNA sequences. Nested case-control and cohort analyses will be used to determine risk factors for these abnormalities, and their association with risk of subsequent NHL |